The First Gene: The Birth of Programming, Messaging and Formal Control

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The Best Mentor You Can Find is Up to You!

Eighteen grants at 17 institutions are expected to create or implement cancer control, prevention, research, and training programs in minority and underserved populations. June 7, —President Clinton issued an executive memorandum directing the Medicare program to reimburse providers for the cost of routine patient care in clinical trials. The memorandum also provides for additional actions to promote the participation of Medicare beneficiaries in clinical studies. December 3, —As part of a national commitment to identify and address the underlying causes of disease and disability in racial and ethnic communities, NCI established the Center to Reduce Cancer Health Disparities.

Because these communities carry an unequal burden of cancer-related health disparities, NCI is working to enhance its research, education, and training programs that focus on populations in need. May 10, —FDA approval of the drug Gleevec, also known as STI, is announced as an oral treatment for chronic myelogenous leukemia. This marked the approval of the first molecularly targeted drug that directly turns off the signal of a protein known to cause a cancer. Clinical trials expanded as investigators tested Gleevec in a variety of cancers that share common molecular abnormalities.

July 24, —The largest-ever prostate cancer prevention study was launched by NCI and a network of researchers known as the Southwest Oncology Group. The Selenium and Vitamin E Cancer Prevention Trial is designed to determine if these two dietary supplements can protect against prostate cancer which is the most common form of non-skin cancer in men.

The study is expected to include a total of 32, men. September 4, —NCI and the American College of Radiology Imaging Network launched 3-year multicenter study of digital mammography, called the Digital Mammographic Imaging Screening Trial, the first large, multicenter study to compare digital mammography to standard mammography for the detection of breast cancer. September 10, —NCI launched the Consumer Advocates in Research and Related Activities program—a landmark initiative convening a network of dedicated advocates who bring the viewpoint of those affected by cancer to NCI.

February 7, —Scientists from NCI and FDA reported that patterns of proteins found in patients' blood may reflect the presence of ovarian cancer, even at early stages. This new diagnostic concept is potentially applicable to the diagnosis of other diseases. May 19, —Researchers from NCI reported that the molecularly targeted drug bevacizumab slowed tumor growth in patients with metastatic renal cell carcinoma, the most common form of kidney cancer in adults. June 19, —NCI scientists used microarray technology to determine the patterns of genes that are active in tumor cells from which they could predict whether patients with the most common form of non-Hodgkin lymphoma in adults are likely to be cured by chemotherapy.

July 16, —The National Heart, Lung, and Blood Institute NHLBI of NIH stopped a major clinical trial early of the risks and benefits of combined estrogen and progestin in healthy menopausal women due to an increased risk of invasive breast cancer. The large multi-center trial, a component of the Women's Health Initiative WHI , also found increases in coronary heart disease, stroke, and pulmonary embolism in study participants on estrogen plus progestin compared to women taking placebo pills. The trial showed that postmenopausal women who used estrogen replacement therapy for 10 or more years were at significantly higher risk of developing ovarian cancer than women who never used hormone replacement therapy.

September 18, —NCI launched the National Lung Screening Trial to compare spiral computed tomography and single-view chest x-ray for early lung cancer in 50, current and former heavy smokers. The trial will examine the relative risks and benefits of both tests at 30 study sites throughout the United States. September 19, —NCI researchers demonstrated that a new approach to cancer treatment, that replaces a patient's immune system with cancer-fighting cells produced in the laboratory specifically to destroy their tumors, can lead to tumor shrinkage.

The experimental technique, known as adoptive transfer, has shown promising results in patients with metastatic melanoma who have not responded to standard treatment. October 16, —NCI and FDA scientists found that patterns of proteins in patients' blood, called prostate-specific antigen PSA , may help distinguish between prostate cancer and benign prostate conditions. PSA is a protein produced by cells of the prostate gland. The blood level of PSA is often elevated in men with prostate cancer. The technique may be useful in deciding whether to perform a biopsy in men with elevated levels of PSA.

October 31, —NCI researchers have discovered that a molecule best known for its antimicrobial properties also can activate key cells in the immune response. This newly discovered function suggests the molecule, a peptide called Beta-defensin 2, may be useful in the development of more effective cancer vaccines. The goal of the IOTF is to leverage the expertise and capabilities of both agencies to streamline and accelerate the overall development of diagnostic, preventive, and therapeutic interventions for cancer.

June 24, —Results of the Prostate Cancer Prevention Trial, testing the effectiveness of finasteride to prevent the disease, were announced about a year earlier than expected. There was a note of caution, however; the men who did develop prostate cancer while taking finasteride were more likely to have high-grade tumors.

September 2, —Death rates from the four most common cancers—lung, breast, prostate, and colorectal—continued to decline in the late s according to data from the Annual Report to the Nation on the Status of Cancer, This report provides an annual update of cancer incidence, mortality, and trends in the United States. November 6, —NCI scientists demonstrated that the growth factors interleukin-2 IL-2 and IL have contrasting roles in the life and death of lymphocytes, an observation that has implications for the immunotherapy of cancer and autoimmune diseases.

September 13, —NCI announced the Alliance for Nanotechnology in Cancer, a five-year initiative to integrate nanotechnology development into basic and applied cancer research to facilitate the rapid application of this science to the clinic. Nanotechnology is a field of research that deals with the engineering and creation of things from materials that are less than nanometers one-billionth of a meter in size, especially single atoms or molecules.

Nanotechnology offers the means to target treatments directly and selectively to cancerous cells and neoplasms. For women with this type of aggressive breast cancer, the addition of trastuzumab to chemotherapy appears to virtually reverse prognosis from unfavorable to good. May 6, —NCI announced the Community Networks Program, a five-year initiative to reduce cancer disparities in minority and underserved populations through community participation in education, research, and training.

September 16, —Preliminary results from a large clinical trial of digital versus film mammography showed no difference in detecting breast cancer for the general population of women in the trial. However, those women with dense breasts, who are pre- or perimenopausal or who are younger than age 50, may benefit from having a digital rather than a film mammogram.

September 28, —NCI and the National Institute of Neurological Disorders and Stroke NINDS created Rembrandt Repository for Molecular Brain Neoplasia Data , a joint informatics initiative to molecularly characterize a large number of primary brain tumors and to correlate those data with extensive retrospective and prospective clinical data. October —NCI initiated the Patient Navigator Research Program PNRP to assess the impact of patient navigators on providing timely and quality standard cancer care to patients following an abnormal cancer finding.

The PNRP was designed to encourage research collaborations and partnerships with organizations serving diverse underserved communities within cancer care delivery systems. The report's authors attribute the declines in death rates to progress in prevention, early detection, and treatment. November 7, —NCI launched a cancer biorepository pilot project designed to standardize biospecimen collection and management among investigators of Specialized Programs of Research Excellence for prostate cancer to enhance the quality and availability of various biospecimens and associated data for the broader scientific community.

December 7, —Results from several studies presented at the San Antonio Breast Cancer Symposium validated that a test called Oncotype DX can predict the risk of breast cancer recurrence in a sizable group of patients. The studies also appeared to identify which of those patients might benefit most from chemotherapy. The studies were heralded by researchers as an important moment in the move toward individualized cancer care. December 13, —NCI and the National Human Genome Research Institute launched a comprehensive effort to accelerate an understanding of the molecular basis of cancer through the application of genome analysis technologies, especially large-scale genome sequencing.

The overall effort, called The Cancer Genome Atlas, began with a pilot project to determine the feasibility of a full-scale effort to systematically explore the universe of genomic changes involved in all types of human cancer. April 17, —Initial results of the Study of Tamoxifen and Raloxifene showed that the drug raloxifene, used to prevent and treat osteoporosis in postmenopausal women, works as well as tamoxifen in reducing breast cancer risk for postmenopausal women at increased risk of the disease. June 7, —Gene profiling, a molecular technique that examines many genes simultaneously, was shown to accurately distinguish between two types of immune cell tumors, Burkitt's lymphoma and diffuse large B-cell lymphoma DLBCL.

Burkitt's lymphoma and DLBCL appear similar when viewed under a microscope but correct diagnosis is critical because each requires very different treatments. Nearly two decades before, researchers at NCI and other institutions began searching for the underlying causes of cervical cancer. That scientific quest led to the vaccine Gardasil human papillomavirus [HPV] vaccine, quadrivalent , which protects against infection from the two types of human papillomavirus that cause the majority of cervical cancers worldwide. June 29, —Researchers at NCI identified a link between inherited and acquired genetic factors that dramatically increase the chance of developing a very common type of melanoma.

The Melanoma Risk Assessment Tool can be used by health professionals to identify individuals at increased risk of melanoma, help them plan for regular screening, and potential. October 5, —The Biomarkers Consortium, a public-private biomedical research partnership composed of The Foundation for the National Institutes of Health, NIH, FDA, and the Pharmaceutical Research and Manufacturers of America, formed to search for and validate new biomarkers to accelerate the delivery of new technologies, medicines, and therapies for prevention, early detection, diagnosis, and treatment of disease.

October 18, —NCI released new data from the Cancer Genetic Markers of Susceptibility CGEMS study on prostate cancer intended to help identify genetic factors that influence the disease and could be integral to the discovery and development of new, targeted therapies. This was the first public release of a whole-genome association study of cancer—such studies examine the entire genome, with no assumptions about which genetic alterations cause cancer.

Adding an MRI scan to the diagnostic evaluation effectively doubled the number of cancers immediately found in these women. Age-adjusted breast cancer incidence rates in women in the United States fell 6. Prescriptions for HRT also declined rapidly in and May 8, —Researchers from NCI and Baylor College of Medicine found that people infected with the hepatitis C virus are at an increased risk of developing certain lymphomas cancers of the lymphatic system.

June 14, —NCI launched the three-year pilot phase of a new program that will help bring state-of-the-art cancer care to patients in community hospitals across the United States. November 27, —A new model for calculating invasive breast cancer risk the CARE model was found to give better estimates of the number of breast cancers that would develop in African American women 50 to 79 years of age than an earlier model which was based primarily on data from white women. January —Scientists reported that results of a randomized phase III clinical trial show that a combination of low oral doses of difluoromethylornithine and sulindac greatly reduces the recurrence of colon polyps and is safe and well tolerated.

March 6, —DNA mutations found in a type of non-Hodgkin lymphoma that has a poor prognosis led researchers to a better understanding of how the cancer develops and how it might be treated. April 21, —Researchers identified a pattern of gene activity in mice that may help to predict individual risk for breast cancer metastasis and survival in humans. June 23, —NCI researchers found that cells from a blood-borne cancer called multiple myeloma rely on the activity of a single protein, IRF4, for the activation of a wide range of genes responsible for cell survival and spread.

Blocking the production of this protein can be strikingly effective in eliminating cancer cells in laboratory models of multiple myeloma. January 1, —Scientists identified mutations in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia ALL. Although further research is needed, the findings are likely to provide the basis for future diagnostic tests to assess the risk of treatment failure.

By using a molecular test to identify this genetic marker in ALL patients, physicians should be better able to determine appropriate therapies. February 11, —Researchers established that abnormal white blood cells can be present in patients' blood more than six years prior to the diagnosis of a chronic form of lymphocytic leukemia. This finding may lead to a better understanding of the cellular changes that characterize the earliest stages of the disease and how it progresses.

March 18, —A new report from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, designed to provide answers about the effectiveness of prostate cancer screening, showed that six annual screenings for prostate cancer led to more diagnoses of the disease, but no fewer prostate cancer deaths. August 14, —Results of a randomized phase III clinical trial show that targeted therapy with the drug imatinib mesylate Gleevec reduces disease recurrence following surgery to remove a localized gastrointestinal stromal tumor. October 5, —Researchers identified a gene that may play a role in the growth and spread of a childhood cancer called rhabdomyosarcoma, which develops in the body's soft tissues.

The finding revealed a potential new target for the treatment of this disease. October 7, —Researchers found that a small RNA molecule, known as a microRNA, may help physicians identify liver cancer patients who, in spite of their poor prognosis, could respond well to treatment with a biological agent called interferon. December 18, —Initial results from a large, randomized clinical trial for patients with multiple myeloma, a cancer of the blood and bone marrow, showed that patients who received the oral drug lenalidomide Revlimid, also known as CC following a blood stem cell transplant avoided recurrences longer than patients who received a placebo.

January 6, —Researchers with a study conducted at NCI, the National Institute for Allergy and Infectious Diseases, and the National Human Genome Research Institute, discovered genetic mutations that may contribute to the development of an aggressive form of non-Hodgkin lymphoma. These findings provided insight into a mechanism that cancer cells may use to survive, thus identifying potential new targets for treatment of the disease.

January 19, —Researchers found that the most common form of malignant brain cancer in adults, glioblastoma multiforme, is not a single disease but appears to be four distinct molecular subtypes that respond to aggressive chemotherapy and radiation differently, according to a study by The Cancer Genome Atlas Research Network. April 19, —Long-term results show that Raloxifene, a common osteoporosis drug, prevented breast cancer to the same degree, but with fewer serious side-effects than the drug Tamoxifen that had been in use many years for breast cancer prevention as well as treatment.

In particular, there was significantly less endometrial cancer with raloxifene use. November 10, —Researchers discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia, an aggressive blood cancer that kills 9, Americans annually. December 23, —NCI announced major changes to the long-established Clinical Trials Cooperative Group Program that conducts many of the nationwide trials of new cancer therapies. In a major transformation, NCI intends to consolidate the nine groups that currently conduct trials in adult cancer patients into four state-of-the-art entities that will design and perform improved trials of cancer therapies.

The changes are designed to provide greater benefits for cancer patients and more information for researchers. These moves come in response to an NCI-requested April report from the Institute of Medicine, which called for a series of changes to the cooperative groups program, including restructuring. The NCI Cooperative Group program, founded over 50 years ago, involves more than 3, institutions and 14, investigators, and the program enrolls over 25, patients in clinical trials each year. March 10, —The number of cancer survivors in the United States increased to There were 3 million cancer survivors in and 9.

March 31, —Rates of death in the United States from all cancers for men and women continued to decline between and , the most recent reporting period available, according to the latest Annual Report to the Nation on the Status of Cancer. June 5, —NCI announced clinical trial results showing that in a high-risk form of pediatric acute lymphoblastic leukemia, a high-dose schedule of a drug raises already high cure rates even higher.

June 29, —An analysis of genomic changes in ovarian cancer has provided the most comprehensive and integrated view of cancer genes for any cancer type to date. TCGA researchers completed whole-exome sequencing, which examines the protein-coding regions of the genome, on an unprecedented tumors. Two doses of the human papillomavirus vaccine HPV Cervarix were as effective as the current standard three-dose regimen after four years of follow-up.

January 19, —A clinical trial has shown that addition of chemotherapy to radiation therapy leads to a near doubling of median survival time in patients with a form of brain tumor oligodendroglioma that carries a chromosomal abnormality called the 1p19q co-deletion. Federal government scientists reported that heavy exposure to diesel exhaust increased risk of death from lung cancer. March 8, —In a new examination of United States cancer incidence data, investigators reported that incidence trends have remained roughly constant for glioma, the main type of brain cancer hypothesized to be related to cell phone use.

September 27, —Scientists may have discovered why a protein called MYC can provoke a variety of cancers. Like many proteins associated with cancer, MYC helps regulate cell growth. A study carried out by researchers at NIH and colleagues found that, unlike many other cell growth regulators, MYC does not turn genes on or off, but instead boosts the expression of genes that are already turned on.

More than 30 percent of all human cancers are driven by mutations of the RAS family of genes. This approach is called a "hub and spoke" model. September 19, —A world-wide competition to bring emerging breast cancer technologies to market was launched by the Avon Foundation for Women, in partnership with NCI and the Center for Advancing Innovation. Teams were offered the opportunity to create strategic business plans and the potential to start new companies based on the development of 10 unlicensed breast cancer inventions by turning them into commercially marketed products.

Breast cancer inventions include therapeutics, diagnostics, prognostics, one device, one vaccine, and a health IT invention, all from the NCI intramural Center for Cancer Research and Avon Foundation-funded university labs. In a new, complementary report, TCGA experts examined more than GBM samples—the largest to date utilizing genomic characterization techniques and nearly more than were examined in —to identify several additional significantly mutated genes in GBM.

November 13, —A trial conducted by researchers at NCI showed adult patients with a type of cancer known as Burkitt lymphoma had excellent long-term survival rates—upwards of 90 percent—following treatment with low-intensity chemotherapy regimens. Standard treatment for Burkitt lymphoma involves high-dose chemotherapy, which has a high rate of toxicity, including death, and cures only 60 percent of adult patients. November 20, —NCI scientists report that the incidence of oropharyngeal cancer significantly increased during the period among people in countries that are economically developed.

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Recent studies from several countries have reported rising incidence of oropharyngeal cancers and subsequent studies have shown the human papilloma virus HPV as the potential cause. Researchers note that prophylactic HPV vaccine has been shown to protect against oral HPV infection, suggesting an additional benefit of vaccination programs for both women and men. Recent advances in deciphering the cancer genome have enabled the development of targeted therapies.

To explore targeted therapies, cancer clinical trials need to screen large numbers of patients with the same or different histologic tumor types to identify those patients whose tumors contain the distinct molecular targets of the therapies being tested. March 5, — Ten winners of a world-wide competition to bring emerging breast cancer research technologies to market faster were announced today by the Avon Foundation for Women, in partnership with the NCI, and the Center for Advancing Innovation CAI. ALCHEMIST represents three integrated, precision medicine trials that are designed to identify people with early-stage lung cancer who have tumors that harbor EGFR and ALK gene alterations and evaluate whether drug treatments targeted against those molecular changes can lead to improved survival compared to current standard of care therapy alone e.

August 30, —In a large international collaborative analysis of risk factors for non-Hodgkin lymphoma NHL , NCI scientists were able to quantify risk associated with medical history, lifestyle factors, family history of blood or lymph-borne cancers, and occupation for 11 different NHL subtypes, including less common subtypes. These findings provide crucial insight into the diverse factors that drive different NHL subtypes and correspond with their biological and clinical characteristics. The honorees received their medals at a White House ceremony later in as recognition for their outstanding contributions to discoveries that enabled the development of HPV vaccines.

College of Arts and Sciences

NCORP is a national network of investigators, cancer care providers, academic institutions, and other organizations. NCORP conducts multi-site cancer clinical trials and studies in diverse populations in community-based healthcare systems across the United States and Puerto Rico with a goal of NCORP bringing cancer clinical trials and cancer care delivery research to individuals in their own communities. Researchers at NCI intend to use this approach to find new, more effective treatments for various kinds of cancer based on increased knowledge of the genetics and biology of the disease and scientists hope to apply precision medicine to all areas of health and healthcare.

January 27, —In the largest prospective study to date of image-guided technology for identifying suspicious regions of the prostate to biopsy, NCI researchers compared the ability of this technology to detect high-risk prostate cancer with that of the current standard of unguided prostate biopsy. April 20, —A new NCI study shows that inherited variations in a known tumor suppressor gene among children and adolescents with osteosarcoma, a cancer of the bone, are more common than previously thought.

Older patients who are also susceptible to this malignancy were not found to carry mutations in the gene, known as TP August 13, —Using novel large-scale imaging technology, NCI intramural researchers announced they have mapped the spatial location of individual genes in the nucleus of human cells and identified 50 cellular factors required for the proper three-dimensional 3D positioning of genes.

These spatial locations play important roles in gene expression, DNA repair, genome stability, and other cellular activities. The goal is to double the rate of progress against cancer, achieving in five years what otherwise would have taken ten. May 16, —NCI scientists found that leisure-time physical activity was associated with lower risks of 13 cancer types esophageal adenocarcinoma, liver, lung, kidney, gastric cardia, endometrial, myeloid leukemia, myeloma, colon, head and neck, rectal, bladder, and breast. Most of these associations were evident regardless of body mass index or smoking history.

These findings confirm and extend the evidence for a benefit of physical activity on cancer risk and support its role as a key component of population-wide cancer prevention. This data sharing platform promotes precision medicine in oncology. It is an expandable knowledge network supporting the import and standardization of genomic and clinical data from cancer research programs. As more researchers add clinical and genomic data to the GDC, it will become an even more powerful tool for making discoveries about the molecular basis of cancer that may lead to better care for patients.

December 7, — In a study of an immune therapy for colorectal cancer that involved a single patient, researchers identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene. December 28, —In an early-phase intramural clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 NF1 and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage.

At present, no therapies are considered effective for NF1-related large plexiform neurofibromas, but, in this trial, partial responses, meaning 20 percent or more reduction in tumor volume, were observed in over 70 percent of the patients. NF1 affects 1 in 3, people. February 4, —Senator M. Neely, West Virginia, introduced Senate Bill to authorize a reward for the discovery of a successful cure for cancer. March 7, —Senator M. Neely introduced Senate Bill to authorize the National Academy of Sciences to investigate the means and methods for affording Federal aid in discovering a cure for cancer and for other purposes.

April 23, —Senator W. Harris, Georgia, introduced Senate Bill to authorize the Public Health Service and the National Academy of Sciences jointly to investigate the means and methods for affording Federal aid in discovering a cure for cancer and for other purposes. April 2, —Senator Homer T. April 29, —Congressman Maury Maverick, Texas, introduced House Resolution to promote research in the cause, prevention, and methods of diagnosis and treatment of cancer, to provide better facilities for the diagnosis and treatment of cancer, to establish a National Cancer Center in the Public Health Service, and for other purposes.

The bill also calls upon NCI to assist and promote similar research at other public and private institutions. March 28, —House Joint Resolution , 75th Congress, was passed, "To dedicate the month of April in each year to a voluntary national program for the control of cancer. December 23, —The National Cancer Act of provides increased authorities and responsibilities for the NCI Director; initiating a National Cancer Program; establishing a 3-member President's Cancer Panel and a member National Cancer Advisory Board, the latter replacing the National Advisory Cancer Council; authorizing the establishment of 15 new research, training, and demonstration cancer centers; establishing cancer control programs as necessary for cooperation with state and other health agencies in the diagnosis, prevention, and treatment of cancer; and providing for the collection, analysis, and dissemination of all data useful in the diagnosis, prevention, and treatment of cancer, including the establishment of an international cancer data research bank.

November 9, —The Community Mental Health Centers Act amends the National Cancer Act to emphasize education and demonstration programs in cancer treatment and prevention, and stipulates that NCI devote more resources to prevention, focusing particularly on environmental, dietary and occupational cancer causes. November 4, —The Health Research Extension Act of provides a two-year extension, which reaffirms the special authorities of NCI and added information dissemination mandates.

A representative from the Department of Energy was added to the National Cancer Advisory Board as an ex officio member. June 10, —The NIH Revitalization Act of encourages NCI to expand and intensify its efforts in breast cancer and other women's cancers and authorized increased appropriations. Similar language is included for prostate cancer. Department of Defense breast cancer research. PL July 10, —The Radiation Exposure Compensation Amendments of allow more workers who handled radioactive material for weapons programs to be eligible to receive federal compensation for radiation-induced illness.

Postal Service the authority to issue semipostal stamps, which are sold at a premium in order to help provide funding for a particular area of research. January 4, —The Best Pharmaceuticals for Children Act is designed to improve the safety and efficacy of pharmaceuticals for children, by reauthorizing legislation that encourages pediatric drug research by giving drug companies an incentive of six months of additional market exclusivity to test their products for use in children.

In addition, the CDC is directed to establish and carry out an information and education program. September 10, —The Public Health Security and Bioterrorism Preparedness and Response Act contains a provision instructing Federal agencies to stockpile and distribute potassium iodide KI to protect the public from thyroid cancer in the event of a radiation emergency. June 30, —The Patient Navigator Outreach and Chronic Disease Prevention Act of amends the Public Health Service Act to authorize a demonstration grant program to provide patient navigator services to reduce barriers and improve health care outcomes.

The bill directs the HHS Secretary to require each recipient of a grant under this section to use the grant to recruit, assign, train, and employ patient navigators who have direct knowledge of the communities they serve to facilitate the care of individuals who have cancer or other chronic diseases. The bill also directs the HHS Secretary to coordinate with, and ensure the participation of, the Indian Health Service, NCI, the Office of Rural Health Policy, and such other offices and agencies as deemed appropriate by the Secretary, regarding the design and evaluation of the demonstration programs.

Postal Service's authority to issue special postage stamps to help provide funding for breast cancer research through December 31, January 12, —The Gynecologic Cancer Education and Awareness Act of , or "Johanna's Law" directs the HHS Secretary to carry out a national campaign to increase the awareness and knowledge of health care providers and women with respect to gynecologic cancers. April 20, —The National Breast and Cervical Cancer Early Detection Program Reauthorization Act of allows states to apply for federal waivers to spend a greater share of funds on hard-to-reach underserved women.

Requires NIH to expand the clinical trial registry clinicaltrials. Postal Service to issue a special postage stamp which contributes to funding breast cancer research. July 29, —The Caroline Pryce Walker Childhood Cancer Act of amends the Public Health Service Act to advance medical research and treatments into pediatric cancers, ensure patients and families have access to the current treatments and information regarding pediatric cancers, establish a population-based national childhood cancer database, and promote public awareness of pediatric cancers.

October 8, —The Breast Cancer and Environmental Research Act of amends the Public Health Service Act to authorize the Director of the National Institute of Environmental Health Sciences to make grants for the development and operation of research centers regarding environmental factors that may be related to the etiology of breast cancer.

The Act allows the Secretary of HHS to restrict the sale or distribution and the advertising or promotion of tobacco products, if appropriate for the protection of the public health, and to the full extent permitted by the First Amendment. March 23, —The Patient Protection and Affordable Care Act HR , the health care reform bill, establishes a private non-profit institute called the Patient-Centered Outcomes Research Institute to conduct comparative clinical effectiveness research, obtain and use data from the Federal government, and establish advisory panels to advise on research priorities, among other provisions.

The bill requires NIH to conduct research to develop and validate new screening tests for breast cancer. The bill also requires the NIH Director to establish a Cures Acceleration Network CAN program, which shall award grants and contracts to eligible entities to accelerate the development of high need cures and therapies, including the development of medical products, drugs or devices, or biological products.

E is for Energy : the spirit that catalyzes us. Gracious people give of themselves. Gracious people leverage who they are and what they have for the benefit of others. Gracious leaders share time, knowledge, and power. They cultivate a selfless approach to life. Generosity emanates from an abundance mindset. A selfless person, even in the midst of personal adversity, can find something to share with others.

That attitude is contagious. Self-awareness opens the door to respect for others. A fully self-aware person knows her faults as well as her strengths. Such awareness compels the self to acknowledge the dignity of others. Respect and self-respect fuel each other. They grow together. Grace is intentional. A reactive mind rarely manifests grace. While grace that has been shown to us comes freely, it requires effort for us to generate it ourselves.

Grace means rising above a perceived slight. Grace is often manifested in clarity of purpose and civility. Civility is a decision we make. They focus not on themselves, but on the needs of others—on healing. Gracious people have the capacity to forgive and show mercy. Gratitude enables compassion—both gratitude expressed and felt. We need to reframe our lives with a constant awareness of just how important feeling gratitude within ourselves is because it actually helps our overall well-being.

Grace requires energy. In forgiveness, mercy, joy, and humor. When we demonstrate grace in our leadership, it spills into other areas of our life as well because it is an approach to life. Our example encourages others to begin to think that way as well. Grace—in all of the dimensions Baldoni explores in this book—is a value that has fallen on hard times. It is time to revive it in our personal lives, in the workplace, social media, and in public discourse.

Grace celebrates grace as well as advocates for it. Baldoni shares many examples of people from all walks of life who demonstrate grace in their lives. They are an inspiration to us all. Grace reduces the space between us. Our environment often pushes us into negativity; into the differences between us. Grace intentionally overlooks the negative and leverages the positive. It finds the connection and promotes it. Baldoni breaks the often intangible idea of grace into down-to-earth actionable behaviors that we can all intentionally implement into our lives.

You will find a self-assessment tool of 20 questions to help you take an honest look at how much you have allowed grace to fill your thoughts and behaviors. Charles Fred initiated a study of over post-startup business to find out why, after they had experienced early growth, had stagnated.

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  8. What the researchers found is a problem in the way employees approached their roles, solved problems, and interacted with each other; poor-performing firms showed working environments of intense stress. Our culture baits us into a non-stop frantic pace with the inevitable unintentional behaviors. Many leaders believe that they are just setting the bar for high performance. So, when we require mental acuity, we experience diminished recall. When we need sharp thinking and problem-solving, our minds are full.

    Into this environment, Charles Fred introduces a leadership discipline that inserts pause and calls it The 24 Hour Rule. Pause is not a delay but a discipline. It allows us to control how we respond and react to others, whether it takes five seconds or 24 hours. Most importantly, it does not delay our ambitions or dampen the need to hustle. Instead, we begin each day with unknown situations, variables well beyond our ability to plan and prepare. For these reasons, a leader must use self-discipline—the ability to mentally call a time-out, to get rest, to run through a checklist—despite overwhelming temptations to quickly react or respond without doing so.

    It is the one thing we have complete control over. When we look at the highlight reel of successful people, it gives us the impression that they are always on—always producing. As we watch from the sidelines, we create for ourselves a false set of expectations. We introduce unnecessary stress into our lives and work as we try to keep up. Top producers insert pause into their work. We need the self-discipline to do the same by letting go of a false ideal. The 24 Hour Rule is a well thought out and well-executed booklet.

    Fred provides three steps for building self-discipline around pause. It is a quick read but one that is worth spending some time thinking about. Productivity is not about doing more faster. We undermine our potential when we try to do everything. Freedom to focus, Freedom to be present. Freedom to be spontaneous. Freedom to do nothing. To that end, Michael Hyatt presents in Free to Focus , 9 actions grouped into 3 steps.

    To start, you must stop. Formulate : What do you want your life to look like? What matters to you most. What does that look like for you? Evaluate : Where are you now? What should you be doing? Evaluate what you do and could do based on two key criteria: passion and proficiency. The desire zone is where your passion and proficiency intersect and where you can make the greatest contribution.

    Obviously, this is where you want to be functioning most of the time. Hyatt adds a fifth zone called the Development Zone. This is an area where you are passionate about and developing a proficiency, or passionate about but not yet proficient. We need to evaluate all of our tasks and place them in the appropriate zone. Rejuvenate : Make time to rejuvenate. We can increase the energy we direct at our why when we sleep, eat right, move, connect, play, reflect, and unplug.

    Eliminate : Every yes contains a no. Time is a zero-sum game. Then go find it. Delegate : Should I be doing this job at all? Tasks in your Drudgery and Disinterest Zones should be delegated. The items in your Distraction Zone may be harder to let loose of since you enjoy them even though you are not the most proficient at them. Better to give them over to someone who can do them much better.

    If you have more than you can handle in your Desire Zone, you should look at delegating some of those too. So, while delegation does, in fact, take more time on the front end, it will save you an enormous amount of time every instance after that. Consolidate : Harness the power of MegaBatching.

    In those dedicated blocks of time, I truly am free to focus on the thing that matters most at that moment. Designate : Decide what needs to be done now and what can be done later. Plan your ideal week. Designate the what and when of your week and day. Limit instant communications by turning off your notifications.

    Set boundaries by letting people know in advance that you are going offline for a period of time to focus. Use technology to block technology. Listen to the right background music. Take charge of your day. Free to Focus is one of the best books you will read in order to take control of your life. You will find downloadable tools for each step of the process. To some, this comes naturally. Others must constantly work on it. Since my earliest memory, I have had the sense that anything worth doing… worth pursuing… must be passionately pursued.

    A positive attitude naturally follows. I found myself first assuming leadership responsibilities at age 14 when I became an Eagle Scout. For me, getting there was just a mountain to climb. It was the culmination of 21 merit badges and a large community project. It was the excitement of the journey, the arrival at a destination, and the achievement of the reward.

    For me, at 14 years old, it was like reaching the top of Mount Everest but with no real thought or plan on how I was going to get back down… the part of the climb where most people die. But it did help jump-start a lifelong journey to develop and sharpen my leadership skills—a journey that really never ends. Great leaders constantly deal with the struggle between achieving personal goals, while doing so with humility.

    Chapter 5. Socialization

    In high school, I held leadership roles in school government and on the sports field. My agreement sealed my fate. All these experiences helped shape my thinking about, and commitment to, leadership because people started to turn to me to lead. I had the right attitude throughout these early years. However, there came a period in college when I lost my way. My attendance at Purdue was facilitated by an Army ROTC scholarship, at a time when the Vietnam War was stoking nationwide protests across nearly every college campus.

    Compared to other campuses, Purdue was a fairly conservative school, but we had a chapter of the Students for Democratic Society SDS , and they regularly protested the war on the mall or at the Armory. I had mixed feelings about the war when I arrived at Purdue in , having spent most of my high school years in Europe—insulated from the anti-war movement. But since I had an ROTC scholarship and my dad was retiring from the Air Force and starting law school about the same time I entered college, I felt an obligation to stay in a program that was paying my way.

    I also worked 4 hours each evening Monday - Friday as a janitor, cleaning the second floor of the university library to help make ends meet. Just walking across campus in uniform to attend military drills drew unwanted attention. So, when the annual Army ROTC awards ceremony occurred in the spring of my freshman year , and knowing that I was not an award recipient, I decided to skip the ceremony and attend the SDS rally in the mall instead. Upon arriving at the armory, they broke open the large truck-sized doors and entered, chanting loud and strong.

    State troopers in riot gear soon arrived to keep the protesters away from the formation of cadets. He called me in the following morning and told me that my scholarship was being put on probation. This was a wakeup call for me, and it began the reshaping of my attitude. I had to decide which side to be on. I came to realize that I wanted to be a leader more than a protestor. Like some other Americans, I may have thought that the Vietnam War was ill-advised, but I also realized that there were alternative ways to make my mark on the world. When ROTC summer camp training rolled around between my junior and senior year, I spent nine weeks at Fort Riley and did well enough to become the third-ranking cadet at Purdue during my senior year.

    Upon graduation from Purdue in , I was one of six cadets designated a Distinguished Military Graduate. You need building blocks to realize that dream. During those early years at Purdue—at least as it applied to an Army career—I lacked ambition, a good self-awareness, and perseverance. I simply knew that I owed four years to the Army after graduation because of my scholarship, but after that, I thought I could move on to something else.

    Consider, for example, all the other concepts that courage connects to in workplace settings. Innovation takes courage because it requires creating ideas that are ground-breaking and tradition-defying; great ideas always start out as blasphemy! And sales always take courage because it requires knocking on the doors of prospects over and over in the face of rejection.

    Having a way of categorizing courageous behavior allows you to pinpoint the exact type of courage that each individual worker may be most in need of building. The first bucket of courage is TRY Courage. TRY Courage is the courage of action. It is the courage of initiative. TRY Courage requires you to exert energy in order to overcome inertia. You experience your TRY Courage whenever you must attempt something for the very first time, as when you cross over a threshold that other people may have already crossed over.

    First attempts; for example, the first time you lead an important strategic initiative for the company. Pioneering efforts, such as leading an initiative that your organization has never done before. Taking action. All courage buckets come with a risk, and the risk is what causes people to avoid behaving with courage. The risk associated with TRY Courage is that your courageous actions may harm you, and, perhaps more importantly, other people.

    If you act on the risk and wipe out, not only are you likely to be hurt, but you could also potentially harm those around you. It is the risk of harming yourself or others that most commonly causes people to avoid exercising their TRY Courage. TRUST Courage is very hard for people who tend to be controlling and those who have been burned by trusting people in the past.

    Following the lead of others, such as letting a direct report facilitate your meeting. Presuming positive intentions and giving team members the benefit of the doubt. By trusting others, you open yourself up to the possibility of your trust being misused. Thus, many people, especially those who have been betrayed in the past, find offering people trust very difficult. For them, entrusting others is an act of courage. TELL Courage is what is needed to tell the truth, regardless of how difficult that truth may be for others to hear. It is the courage to not bite your tongue when you feel strongly about something.

    TELL Courage requires independence of thought. Speaking up and asserting yourself when you feel strongly about an issue. Using constructive confrontation, such as providing difficult feedback to a peer, direct report, or boss. TELL Courage can be scary and comes with risks too. Courage is Contagious. Understanding and influencing courageous behavior requires that you be well versed in the different ways that people behave when their courage is activated.

    By acting in a way that demonstrates these different types of courage, and by fostering an environment that encourages them, you can make your company culture a courageous one where employees innovate and grow both personally and professionally. A former member of the U. High Diving Team, Bill is considered the originator of the new organizational development practice of courage-building.

    Department of Veterans Affairs. The only questions are what and how much. Poor choices lead you into failure, and good choices take you out of failure. Nobody likes failure. We are lead to believe that failure means that there is something wrong with us. Failure simply represents a challenge; not something to avoid. We crave certainty, and that feeds our fears. The lesson of Fail More is to keep going. But your purpose will compel you to keep going, adapt, and grow. Rowling, David Neeleman, and other well-known and not so well-known individuals, but he includes his own experiences that give it depth and credibility.

    Fail More will help you to work past your fears, the obstacles, set realistic goals, and learn from every result. Success is a process, and failure is part of that process. Failure gives you the critical feedback you need to make the necessary adjustments to bring you closer to your goal. Life serves adversity as a barrier to entry in the pursuit of happiness..

    Look within as you work to create value for people by first becoming of value to yourself.. Enjoy the fruits of your labor while you are engaged in their pursuit. We all start at a place where we need to improve if we are going to succeed on a more significant scale. Procrastination, lack of prioritization, and the absence of goals all have their origins in fear.

    In order to get what you want, you have to do those things that give you the confidence to do just a little bit more the next day. Thomas Jefferson was skilled in many fields. In December , John F. Jefferson dined here alone. Jefferson cared for people and always offered advice when asked. A year before his death, he was asked by a father to give some counsel to his young son, Thomas Jefferson Smith.

    He responded with a letter that began:. Monticello Feb. Th: Jefferson to Th: Jefferson Smith. The letter concluded with ten rules to live by Jefferson titled A Decalogue of Canons for observation in practical life :. Never put off till tomorrow what you can do to-day. Never trouble another for what you can do yourself. Never spend your money before you have it. Never buy a what you do not want, because it is cheap; it will be dear to you. Pride costs us more than hunger, thirst and cold.

    We never repent of having eaten too little. Nothing is troublesome that we do willingly. How much pain have cost us the evils which have never happened! Take things always by their smooth handle. When angry, count ten, before you speak; if very angry, an hundred. The complete letter can be found on the National Archives website. Like us on Instagram and Facebook for additional leadership and personal development ideas.

    H OW DO YOU stand out in your chosen occupation to get the respect, recognition, and opportunities you want and deserve, to achieve the success you want? Leadership and life are built on relationships. Despite any talent or education you may have, your ability to work with and influence others is what will set you apart. You need a plan. Why am I here?

    You are not a victim. A specific purpose helps you also to align your actions to the purpose of others and your organization. It is nearly impossible to make good life choices with no self-awareness. A good place to get self-awareness is to watch the behavior of others. Often the behaviors that irritate you are mirrors of your own life.

    How do you impact others? Before you interact with others, begin by asking what is the desired result based on who I am, my purpose, and who I want to be? We have an impact on everyone we meet. How do others perceive us? Is that our intent? Does it align with our purpose? The other part of the Conscious Success Model is how we differentiate ourselves. We have to be more proactive, more deliberate and consciously aware. This is conscious success.

    How am I presenting myself to others? Am I having the impact I really want to make? This, of course, speaks to having a healthy self-awareness. Each of these differentiators as negative and a positive side. Either side will get you noticed. Avoid the side that will get you noticed for the wrong reasons. Differentiator 1: Authenticity. We mostly lack authenticity because we are trying to be what people want us to be in order to be accepted or popular. We are inauthentic to cover up for our insecurities.

    Authenticity leads to trust. Consistency matters. Differentiator 2: Work Ethic and Personal Responsibility. Decide that you are percent responsible for what happens in your life and everyone else is 0 percent responsible. It might seem unrealistic to do this but deciding to be percent responsible forces you to move forward. Blaming and justifying limits options and percent to zero percent responsibility expands options.

    Differentiator 3: Listening for Results and Connections. Ask questions with the intent of clarifying your understanding. Differentiator 4: Articulate for Impact. Closely related to differentiator 3 on listening is articulation. Have a good vocabulary. Before you speak, consider your emotional state. Also, think about what your purpose is and what you are trying to convey.

    Differentiator 5: Humor. You can have a sense of humor, but it must be consistent with your image and what it is you want to accomplish. Differentiator 6: Gratitude. Gratitude is a choice we make each and every day. Having an attitude of gratitude gives you a positive outlook which makes you more attractive to others. It takes commitment, focus, and a force of will.

    The Conscious Success Model provides a useful framework for not only differentiating yourself but creating a life that matters. The 9 Dimensions of Conscious Success is a great tool to put into the hands of anyone starting out in life. I N , Sir Isaac Newton presented three laws of motion. The first law is often referred to as the Law of Inertia. The law states that every object will remain at rest or continue in a straight line unless compelled to change its state by the action of an external force.

    In other words, things stay the way they are unless something comes along to disrupt them. This law has the power to make us or break us. And it is at work in our lives all day, every day whether we are conscious of it or not. When we kick a soccer ball, it heads in a specific direction until it is acted upon by a force greater than the force that is currently propelling it downfield. Like that soccer ball, our life is moving along a path that is taking us to a particular future intentionally or not. And we will continue along that path to its destination until we do something different.

    Our intentions mean nothing. In other words, our will be just like our unless we exert a force to change our direction that is greater than comfort we enjoy by continuing to do what we have always done producing the same results again and again. No force, no change. Get on a new path. New actions will produce different results. For every cause, there is an effect. Today is connected to tomorrow. Every action we take and everything we say is taking us somewhere. We just need to be sure we are on the path that is taking us where we want to go; a path that is taking us to the person we want to become.

    If we work harder than we did last year, then we will do better. If we sacrifice now, then we are investing in our future. If we reflect, then we will grow. If we improve our leadership, then people will follow us. If we are courageous, then we will inspire. If we are curious, then we will learn.

    If we avoid the trappings of power, then we will stay connected with those we serve. If we surround ourselves with the right people, then we will be enriched and will lift others up. If we are authentic and humble, then we will build trust. If we work this law to our advantage, then we will eradicate regret. If we don't improve, then our circumstances won't improve either. Life naturally pushes us off-course and takes us on tangents. Anything meaningful in life is produced by moving upstream — against the current. We need to make some course corrections. We all do from time to time.

    Of course, this implies getting uncomfortable. As we look at our life, we all have directions that need to be changed. It helps to begin this process by asking ourselves questions and giving serious and honest thought to the answers. What habits are holding me back? What three things do I want to accomplish by ? What does a good day look like? What routines keep me on track? Why do I do what I do? And most importantly, what am I grateful for?

    Then drill down into specific areas of your life:. Do I make time to study and grow spiritually? What habits are draining my time and attention? What activities replenish me? Am I taking time to relax and grow in other areas of interest? Am I sleep deprived? Am I eating healthy and avoiding processed foods? What do I need to change in my diet in ? Am I exercising regularly? Am I drinking enough water? Is my morning and evening routine setting me up for my best day? Am I living within my means? How much do I want to make in ?

    What do I have to do to reach that amount? What weaknesses do I need to minimize? Am I where I would like to be in my work or career? How can I increase the value I bring to work? What relationships are building me up? Are any relationships taking me off-track? Who do I take for granted? Do I support those around me? Do I support and encourage others? Do I focus on building others up? Do I make time for others? Where do I need to grow? What strengths do I need to improve on? What do I need to learn? What books do I need to read?

    What seminars do I need to attend? What can I learn from the mistakes I made in ? The key to moving forward is the first step. Every destination needs to be broken down into incremental markers or indicators on the way to the destination. What is the first thing you need to do to get you moving in the right direction?

    Learning to Lead with Ron Williams

    As you begin, focus on the actions required and not the end result. A small step is easier than a leap. Once the first step is made, it is easier to continue down the right path to your desired destination. Leading Matters is about the journey. The stories he tells here are revolve around the ten elements that shaped his journey and how he relied on these traits in pivotal moments. The elements are relevant to any leader at any level. As he observes, the higher up you go the crises just get bigger and come faster.

    He begins by discussing the foundational elements: humility, authenticity, service, and empathy. He then links them together with courage. Finally, he shows how collaboration, innovation, intellectual curiosity, storytelling, and creating change that lasts, helped him reach his goals. Arrogance sees only strengths, ignores our weaknesses, and overlooks the strengths of others, therefore leaving us vulnerable to catastrophic mistakes. Authenticity and Trust. Authenticity is essential to building trust.

    Leadership as Service. If you take a leadership role as a step toward a personal goal of gathering ever-greater titles, awards, and salaries, you will never see true success in that role. Recognize the service of others. As a leader it is easy to get wrapped up in big projects and ambitious initiatives, and, in the process, to forget the smaller, but no less important, individual acts of service taking place all around you.

    Much of that service supports and enables the widely celebrated success of others. Empathy should always be a factor in making decisions and setting goals. Empathy represents a crucial check on action—placing a deep understanding of and concern for the human condition next to data can lead to decisions that support the wellbeing of all. Courage, on the other hand, compels a leader to take that right action.

    While many people can discern what is right and true, acting on that discernment is more difficult. Even if risk-taking is against your nature, for the good of your organization, you must find the courage to practice it. Collaboration and Teamwork. Certain ground rules circumvented interteam rivalries. First of all, I reminded everyone of our shared goal: we wanted to achieve something great. This led to my final ground rule: team members must be treated with the utmost respect. Innovation presents great opportunities for smart entrepreneurs, not the other way around. Intellectual Curiosity.

    Beyond personal enjoyment, though, this lifelong curiosity has served me well in my career. It has enabled me to engage in meaningful dialog about the world and its future. In challenging moments, great leaders show their true character. If you really want to inspire a team to action, best to engage them with a story. Once they become receptive—once they can imagine themselves as part of your vision—you can back your story up with facts and figures.

    When you turn that dream into a vivid story, you make it so attractive and so real that people will want to share it with you by joining your team. When it came time to respond to change, these companies moved quickly and efficiently, because every employee already understood the company identity and therefore knew how to respond without direct coaching.

    In every profession and career, as we climb to higher leadership positions, the role of facts and data decreases. Any one of them has the potential to derail even the best of leaders. While they may creep up on us, we can see them coming and apply the proper antidote. And even though these seven challenges never really go away, we can create some life habits that keep them at bay. Nieuwhof writes from a been-there-done-that Christian perspective about the issues as they manifest themselves in our lives and follows up each one with a chapter on how to combat it.

    These issues affect everyone and some you'll find hit close to home. Cynicism Disappointment and frustration often end in cynicism. Ask them and they know all about it. It may get us in the door, but character is what determines how far we go.

    NBC - Wikipedia

    Technology just makes it worse. Eliminate hurry from your life. And this comment could pull any of us up short:. For me, the sense that a conversation is going nowhere always carries with it an underpinning of judgment and even arrogance on my part. Which, of course, should drive me right back to my knees in confession. Irrelevance Irrelevance happens when what you do no longer connects to the culture and the people around you. That gap is a factor of how fast things change relative to you.

    Change staves off irrelevance. Get radical about change. Surround yourself with younger people. Seek change to transform you. Burnout Burnout saps the meaning and wonder out of life. Signs of burnout include among other things: your passion fades, you no longer feel your highs and lows, little things make you disproportionately emotional, everybody drains you, nothing satisfies you, and your productivity drops. Getting out of this state begins by admitting it and then figuring out how to live today so you will thrive tomorrow.

    What does that look like? Nieuwhof recommends some concrete steps you can take to bring you back from burnout. Go deep enough and take enough time to recover so that you begin to feel gratitude for the process. Emptiness Ironically, success often makes you feel empty. Humility will win you what pride never will: the affection of others. Other people naturally gravitate toward people who live for a cause beyond themselves. The practical advice found here will benefit anyone on their leadership journey.

    It does not invalidate everything else of its type, rather it is designed to be simpler and thereby memorable and actionable on issues that really matter for people in the work environment. And it is quite straightforward for both accessing yourself and others you work with. Pioneers value possibilities and they spark energy and imagination. Drivers value challenge and they generate momentum. Integrators value connection and they draw teams together.

    Guardians value stability and they bring order and rigor. The authors naturally go into detail on each of these types and give an example of a well-known person that fits that type. They also delve into difference between the types as they relate to stress Pioneers are the least stressed. The trick of course, is to use this knowledge to modify you own behavior. Then you can determine how you might flex your own style to better match the preferences of those around you. For example, too many constraints can completely shut a Pioneer down, while a Guardian may withdraw in an environment that feels too chaotic.

    Knowing these trigger points can help you as a leader to give people more of what they need to excel and less of what will turn them off. I might want to be direct with others but I have learned that I am more productive when I am diplomatic. But being that that is my natural tendency, I probably prefer when people are direct and concise with me. That fact would affect my working style profile.

    They prefer having all of the answers and enjoy zooming into every detail. They grew up in a different time and may have adopted a more novelty-seeking and relationship—focused orientation. Without it we tend to be reactive, disengaged, an unimaginative. The more conscious we are, the faster we adapt, and the higher performing we become.

    Bob Rosen and Emma-Kate Swann wrote Conscious: The Power of Awareness in Business and Life , because they believe that becoming more conscious is critical in our increasingly disruptive and accelerating world. Driven by the need to be right, those obsessed with being smart tend to hoard knowledge, externalize blame, and mismanage relationships and risks. This sabotages our ability to thrive in a constantly changing world. As a result, we stay stuck, biased, and reactive.

    Birth of BASIC

    Staying small and never stepping up is sure to lead to regrets and will undermine your highest potential. Harness the power of introspection by getting to know who you are, where you come from, and why you act the way you do. Get curious and adaptive: deal with complexity and paradox by learning how to expand your mind, leverage your relationships and networks, and overcome unconscious biases. Become more honest and intentional in leadership and life, overcoming the pitfalls of being too safe and cautious while embracing reality.

    Act boldly and responsibly to reach your highest potential: how to champion your higher purpose, stretch people in constructive ways, and be generous in your relationships. To lead change you need a conscious mindset. If we are going to create change, we have to begin with ourselves. That requires that we become more conscious of what pushes us forward—our Accelerators —and what holds us back—our Hijackers.

    Accelerators like courage, drive or determination, deliberate practice, resilience, and vulnerability, drive us forward. Hijackers like self-criticism, cynicism, controlling behavior, aloofness or disengagement, and hyper-competitiveness, hold us back. It is important to know how these things impact your performance and constructively use them or deal with them.

    There are many things that conspire to throw us off-course. Knowing who you want to be in the world and remembering your purpose, will help you to manage these issues and keep you on course. The more conscious we are the less drama we will experience in our lives. Another consequence of being conscious is to be civil. Acts of civility are the small sacrifices we make for the good of all and the sake of harmoniously living and working together. Barack Obama because "he's an Arab. He's a decent, family man, citizen that I just happen to have disagreements with on fundamental issues. Conscious unleashes our full potential as human beings.

    By expanding our minds, enriching our experiences, and shaping our destinies, we discover our purpose in life. Being conscious enables us to approach life as a journey. Equipped with everything we need—an open mind and heart, confidence and resilience, and our capacity for greater consciousness—we embrace the uncertainty of life. Conscious is the accelerator for effective change. If you are a high-performer, it comes with the territory. Graham offers 7 tips for overcoming Imposer Syndrome :. Quite that Inner Voice. Perfection is Slow Death. Mistakes can indicate that you need to prioritize, delegate, or take a break.

    Or they could just be mistakes. Honor Your Accomplishments. Perhaps you attribute your success to luck. We are masters at believing negative feedback while shrugging off the positive. Take time to listen to praise from others and own it. Plan for the Worst-Case Scenario. Stay humble and curious. It will give you unprecedented depth in this day and age. Beyond what I'm sharing here, Switchers is an invaluable resource for those looking to make a career switch.

    And this requires a different approach than the typical job search. She covers the five job search killers, networking and the 2nd Level Contact Strategy, rebranding your social media profile, and crafting your professional identity. Bias is a reality in the hiring process, and can be an especially difficult hurdle for Switchers. Learn to identify it and engage strategies to overcome it such as using your network to become an insider. Your career story is what will convince the hiring manager to pull the trigger and make the offer.

    It should be logical, compelling, attention-getting, and genuine. You need to network to make a career switch. Second- and third level connections are where the action is! Most people in your immediate circle have the same information you do, so the goal is to get their network, because that is where your next opportunity lies. Asking for help makes most of us uncomfortable and we often go to great lengths to avoid doing it. We fear rejection. We fear that people we think less of us.

    But the truth is we need the help and support of others to succeed. To be sure, leadership is fundamentally about asking people for help. Making matters worse, our intuitions about what should make others more likely to help are often dead wrong; our fumbling, apologetic ways of asking for assistance generally make people feel far less likely to want to help.

    We hate imposing on people and then inadvertently, we make them feel imposed upon. But for some reason, we forget that when it is our turn to ask for help. Research shows that people actually like us more when they have been able to help us. It makes them feel good too—unless they feel compelled to help. In-Group Reinforcement.

    Those members of our group are the most likely to help us. The Positive Identity Reinforcement. Most people like to think of themselves as helpful because it is part of what it means to be a good person. We reinforce that with gratitude and appealing to the things that matter to them. They need not bother. The Effectiveness Reinforcement. People want what they do to make an impact—to have meaning.

    If we feel we are not making an impact, we are likely to lose motivation. People need to clearly understand the impact of their helping. Research shows that when people are unable to get any kind of feedback about how well they are doing on a task, they quickly become disengaged from it. Be clear up-front about what you want done and the impact it will have.

    And be sure to follow-up. Let them know how things turned out. Reinforcements is written in an engaging way and is full of solid research to support the approach needed to get the help we need to succeed. It is practical advice for anyone asking for help in a way that will leave both parties feeling good about the relationship.

    How many working hours of the average day do you and your team spend in the Drama Triangle? This triangle was developed as a social model years ago by Stephen Karpman, a student of Dr. Eric Berne, the father of Transactional Analysis. It maps out a type of dysfunctional interaction that is common in the workplace and in our homes as well. Karpman used this triangle to define three points that arise predictably in any dysfunctional real-life drama: the Persecutor, the Victim, and the Rescuer.

    Notice that all three of these are roles we can choose to play, or choose to step back from , at any time. Here are three ways you could choose to respond:.

    The First Gene:  The Birth of Programming, Messaging and Formal Control The First Gene: The Birth of Programming, Messaging and Formal Control
    The First Gene:  The Birth of Programming, Messaging and Formal Control The First Gene: The Birth of Programming, Messaging and Formal Control
    The First Gene:  The Birth of Programming, Messaging and Formal Control The First Gene: The Birth of Programming, Messaging and Formal Control
    The First Gene:  The Birth of Programming, Messaging and Formal Control The First Gene: The Birth of Programming, Messaging and Formal Control
    The First Gene:  The Birth of Programming, Messaging and Formal Control The First Gene: The Birth of Programming, Messaging and Formal Control

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