They are able to modulate neuronal excitability and could promote excitotoxicity Phelan et al.
Interestingly, Li et al. The present study was therefore focused on the gating mechanisms of TRPC1. Electrophysiological experiments were then performed to characterize DHPG-induced response. To examine the consequences on neuronal excitability, we measured spontaneous excitatory postsynaptic current of neurons kept in culture and treated with inhibitors of GABA receptors.
In conclusion, our data suggest that, in hippocampal neurons, stimulation of mGluR5 receptor activates both a store-operated and a store-independent entry of cations through TRPC1 channel, resulting in a depolarization of the membrane potential and in an increased synaptic excitability.
The EMBO journal Role of TRPC1 ion channel in hippocampal neurons. Journal of Alzheimers Disease Journal of molecular neuroscience Advances in experimental medicine and biology Oxidation of 5-hydroxytryptamine and related compounds by Mytilus gill plates. The decarboxylation of amino acids related to tyrosine and their awakening action in reserpine-treated mice.
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Melanin granules and mitochondria. Enzymic oxidtion of psilocine and other hydroxyindoles Biochemical Pharmacology. Oxidation of 1, 4-methylhistamine by mammalian plasma. Observations on the substrate specificity of aminne oxidases. The development of current concepts of catecholamine formation. Specificity of amine oxidase for optically active substrates and inhibitors. The amine oxidases of mammalian plasma.
Observations on spermine oxidase of mammalian plasma.
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Observations on the enzymic decarboxylation of amino-acids by living and by acetone-dried bacteria. Il Farmaco; Edizione Scientifica. Enzymic oxidation of mescaline by mammalian plasma Biochemical Pharmacology. Mitochondrial enzymes and chromaffin granules.
Occurrence of an amine oxidase in horse serum.
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Formation of catechol amines in the animal body. British Medical Bulletin. Observations on the distribution of amine oxidase in invertebrates. Archives of Biochemistry and Biophysics. Metabolism and storage of biogenic amines.
Observations on the distribution of catechol amines and adenosinetriphosphate in the bovine adrenal medulla. The conversion of dihydroxyphenylalanineC14 DOPA to norepinephrine by bovine adrenal medullary homogenates. The Journal of Pharmacology and Experimental Therapeutics. The oxidation of L-amino acids by Mytilus edulis.
Observations on omega-amino-polymethylene trimethylammonium compounds.
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The enzymic hydrolysis of cocaine and alpha-cocaine. Enzymic oxidation of derivatives of ethylenediamine.
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The oxidation of L-amino-acids in the digestive gland of Mytilus edulis. Observations on the intracellular granules of the adrenal medulla. The enzymic hydrolysis of alpha-cocaine. Metabolism of epinephrine and norepinephrine. Pigment formation from tryptamine and 5-hydroxytryptamine in tissues; a contribution to the histochemistry of amine oxidase. Enzymic oxidation of tryptamine derivatives. Localization of adrenaline in cytoplasmic particles of the bovine adrenal medulla. Amine oxidase in the earthworm. Amine oxidase and amine metabolism. D-Amino acid oxidase in the molluscan liver.
Enzymic oxidation of 5-hydroxtryptamone in mammalian and cephalopod tissue.
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Observations on amine oxidase in cephalopods. The inhibition of histaminase by amidines. The pressor amines in the adrenal medulla after irradiation. Enzymic formation of noradrenaline in mammalian tissue extracts. Enzymic oxidation of aliphatic diamines.
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The formation of noradrenaline from dihydroxyphenylserine. Comprehensive Physiology. Neuropathology and Applied Neurobiology. Journal of Cachexia, Sarcopenia and Muscle. Cardiovascular Research. Free Radical Biology and Medicine. American Journal of Physiology - Endocrinology and Metabolism. Translational Research. Journal of Cardiovascular Electrophysiology. Basic Research in Cardiology. Clinical Neurophysiology. Journal of Physiology Paris. Journal of Biological Rhythms. Pflugers Archiv European Journal of Physiology.
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